Ectodysplasins

Transmembrane proteins belonging to the tumor necrosis factor superfamily that play an essential role in the normal development of several ectodermally derived organs. Several isoforms of the ectodysplasins exist due to multiple ALTERNATIVE SPLICING of the MRNA for the protein. The isoforms ectodysplasin A1 and ectodysplasin A2 are considered biologically active and each bind distinct ECTODYSPLASIN RECEPTORS. Genetic mutations that result in loss of function of ectodysplasin result in ECTODERMAL DYSPLASIA 1, ANHIDROTIC.

Also Known As:

Ectodysplasin; Ectodysplasin A, Isoform 1; Ectodysplasin A, Isoform 2; Ectodysplasin A1; Ectodysplasin A2; Ectodysplasin-A; Ectodysplasin A

Carbohydrates: 22023
- Glycoconjugates: 1353
  - Glycoproteins: 24834
    - Membrane Glycoproteins: 2252
      - Ectodysplasins: 112
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intercellular Signaling Peptides and Proteins: 29768
    - Cytokines: 164289
      - Tumor Necrosis Factors: 152
        Ectodysplasins: 112
  - Glycoproteins: 24834
    - Membrane Glycoproteins: 2252
      - Ectodysplasins: 112
  - Membrane Proteins: 10078
    - Membrane Glycoproteins: 2252
      - Ectodysplasins: 112
- Peptides: 82426
  - Intercellular Signaling Peptides and Proteins: 29768
    - Cytokines: 164289
      - Tumor Necrosis Factors: 152
        Ectodysplasins: 112
Biological Factors: 2472
- Intercellular Signaling Peptides and Proteins: 29768
  - Cytokines: 164289
    - Tumor Necrosis Factors: 152
      - Ectodysplasins: 112

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Disease

Drug/Important Bio-Agent (IBA)